2/14/2024 0 Comments Antidote midazolam![]() Due to reluctance to continue with the lower dose all children subsequently received 0.5 mg/kg. On breaking the code these suspicions were partly supported. ![]() Randomisation between two doses ceased after 20 patients since staff, despite being "blinded", perceived there to be a wide variation in response to midazolam and attributed that to the difference in doses. ![]() Anxiety was measured using physiological parameters, a behavioural anxiety score, a parental visual analogue scale, and a telephone questionnaire at 2-7 days after the procedure.įifty patients in total were recruited. Children whom staff and parents felt required sedation for accurate and humane completion of minor procedures were selected. ![]() To compare the safety and efficacy of two doses of oral midazolam, and to assess the drug induced amnesia obtained, when used for conscious sedation of children undergoing minor procedures in the accident and emergency (A&E) setting.Ī two stage trial was completed: an initial prospective, double blinded, randomised trial comparing 0.2 mg/kg midazolam suspension with 0.5 mg/kg, followed by further data collection on the higher dose. ![]()
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